Phosphoinositide 3-kinase in Health and Disease Volume 1

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Free Download Phosphoinositide 3-kinase in Health and Disease: Volume 1 By Tina L. Yuan, Lewis C. Cantley (auth.), Christian Rommel, Bart Vanhaesebroeck, Peter K. Vogt (eds.)
2011 | 310 Pages | ISBN: 3642136621 | PDF | 5 MB
From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here the authors give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here.

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