Blood-Brain Barriers From Ontogeny to Artificial Interfaces, Volume 1

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2006 | 774 Pages | ISBN: 3527310886 | PDF | 8 MB
This first handbook to integrate developmental and cellular aspects combines the different structural and functional features involved in the regulation of brain perfusion and neuronal function. It highlights pharmacological and biomedical applications with sections on drug delivery and disease-related states as well as explaining in detail the role of astrocytes, shown to be an essential link between neurons and cerebral blood vessels. In addition the book studies how the structural elements interact in response to the dynamics of neuronal activities, necessitating adaptive mechanism of the interface. A significant part of the book describes new approaches to how the barrier can be surmised for drug delivery and how it can be mimicked by artificial in vitro systems for drug testing. Finally, the involvement of the barrier in brain diseases is considered, focusing on inflammatory and neurodegenerative disorders of the brain. Covering basic knowledge as well as specific information dealing with very recent progress in blood-brain interface research, this book will be of interest to a broad audience. Content: Chapter 1 Development of the Blood?Brain Interface (pages 9-39): Britta EngelhardtChapter 2 Brain Angiogenesis and Barriergenesis (pages 41-59): Jeong Ae Park, Yoon Kyung Choi, Sae?Won Lee and Kyu?Won KimChapter 3 Microvascular Influences on Progenitor Cell Mobilization and Fate in the Adult Brain (pages 61-74): Christina Lilliehook and Steven A. GoldmanChapter 4 The Endothelial Frontier (pages 75-107): Hartwig WolburgChapter 5 Pericytes and Their Contribution to the Blood?Brain Barrier (pages 109-127): Markus RamsauerChapter 6 Brain Macrophages: Enigmas and Conundrums (pages 129-165): Frederic Mercier, Sebastien Mambie and Glenn I. HattonChapter 7 The Microglial Component (pages 167-188): Ingo Bechmann, Angelika Rappert, Josef Priller and Robert NitschChapter 8 The Bipolar Astrocyte: Polarized Features of Astrocytic Glia Underlying Physiology, with Particular Reference to the Blood?Brain Barrier (pages 189-208): N. Joan AbbottChapter 9 Responsive Astrocytic Endfeet: The Role of AQP4 in BBB Development and Functioning (pages 209-236): Grazia P. Nicchia, Beatrice Nico, Laura M. A. Camassa, Maria G. Mola, Domenico Ribatti, David C. Spray, Alejandra Bosco, Maria Svelto and Antonio FrigeriChapter 10 The Role of Fibroblast Growth Factor 2 in the Establishment and Maintenance of the Blood?Brain Barrier (pages 237-246): Bernhard ReussChapter 11 Cytokines Interact with the Blood?Brain Barrier (pages 247-264): Weihong Pan, Shulin Xiang, Hong Tu and Abba J. KastinChapter 12 Insulin and the Blood?Brain Barrier (pages 265-285): William A. Banks and Wee Shiong LimChapter 13 Glucocorticoid Hormones and Estrogens: Their Interaction with the Endothelial Cells of the Blood?Brain Barrier (pages 287-312): Jean?Bernard DietrichChapter 14 Metalloproteinases and the Brain Microvasculature (pages 313-334): Dorothee Krause and Christina LohmannChapter 15 Modeling the Blood?Brain Barrier (pages 335-355): Romeo Cecchelli, Caroline Coisne, Lucie Dehouck, Florence Miller, Marie?Pierre Dehouck, Valerie Buee?Scherrer and Benedicte DehouckChapter 16 Induction of Blood?Brain Barrier Properties in Cultured Endothelial Cells (pages 357-374): Alla Zozulya, Christian Weidenfeller and Hans?Joachim GallaChapter 17 Artificial Blood?Brain Barriers (pages 375-401): Luca Cucullo, Emily Oby, Kerri Hallene, Barbara Aumayr, Ed Rapp and Damir JanigroChapter 18 In Silico Prediction Models for Blood?Brain Barrier Permeation (pages 403-428): Gerhard F. Ecker and Christian R. NoeChapter 19 The Blood?Brain Barrier: Roles of the Multidrug Resistance Transporter P?Glycoprotein (pages 429-461): Sandra Turcotte, Michel Demeule, Anthony Regina, Chantal Fournier, Julie Jodoin, Albert Moghrabi and Richard BeliveauChapter 20 Targeting of Neuropharmaceuticals by Chemical Delivery Systems (pages 463-500): Nicholas Bodor and Peter BuchwaldChapter 21 Drug Delivery to the Brain by Internalizing Receptors at the Blood?Brain Barrier (pages 501-520): Pieter J. Gaillard, Corine C. Visser and Albertus (Bert) G. de BoerChapter 22 Blood?Brain Transfer and Metabolism of Oxygen (pages 521-549): Albert GjeddeChapter 23 Functional Brain Imaging (pages 551-599): Gerald A. DienelChapter 24 Inflammatory Response of the Blood?Brain Interface (pages 601-618): Pedro M. Faustmann and Claus G. HaaseChapter 25 Stroke and the Blood?Brain Interface (pages 619-647): Marilyn J. CipollaChapter 26 Diabetes and the Consequences for the Blood?Brain Barrier (pages 649-669): Arshag D. MooradianChapter 27 Human Parasitic Disease in the Context of the Blood?Brain Barrier - Effects, Interactions, and Transgressions (pages 671-700): Mahalia S. Desruisseaux, Louis M. Weiss, Herbert B. Tanowitz, Adam Mott and Danny A. MilnerChapter 28 The Blood Retinal Interface: Similarities and Contrasts with the Blood?Brain Interface (pages 701-724): Tailoi Chan?Ling

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