Affinity And Efficacy The Components Of Drug-Receptor Interactions

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Affinity And Efficacy: The Components Of Drug-Receptor Interactions
English | 2015 | ISBN: 9814322563 | 750 Pages | PDF (True) | 102 MB
The interaction of a drug with a receptor generates a code of information having components of affinity and efficacy. How this information is translated into a response depends on the unique cells, tissue, organ or system in which the receptor resides. This book describes how to analyze various responses to estimate the affinity and efficacy components of the initial drug-receptor interaction. More specifically, it describes how to measure the affinity and efficacy of drugs through the analysis of single receptor activity, the activation state of a population of receptors, and responses downstream from receptor activation. More light is thrown on ligand-gated ion channels and G protein-coupled receptors in this book.


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